Endocrine Abstracts

Background: Cardiovascular disease (CVD) is the leading cause of death in persons with type 1 diabetes (T1DM). However, there are no CVD-risk prediction models for this population in widespread use and those developed from general population and type 2 diabetes have been shown to underestimate CVD-risk in T1DM. Recently, the Steno Type 1 Risk Engine (ST1RE) was developed for predicting CVD in a cohort of T1DM persons without clinical CVD. We investigate the relationship betwee...

Aims: To evaluate real-world efficacy of closed-loop systems (CLS) (MinimedTM 780G, DBLG1 -Diabeloop- and Control-IQTM Tandem) as well as to assess those predictive factors related with the achievement of near-normal glycemic control.Methods: A prospective, longitudinal, and observational study was performed. It included T1D adults who initiated CLS between April and December 2021 in our hospital and provided data for ≧3 months (...

Introduction: Graves’ ophthalmopathy (GO) is an orbital autoimmune disorder closely linked to thyroid autoimmunity, mainly Graves’ disease. After an initial progressive inflammatory period (active phase), GO stabilizes and eventually subsides (inactive phase). Treatment should rely on a thorough assessment of the activity and severity of GO and its impact on the patient’s quality of life. Patients with active, mild disease generally benefit from local therapies ...

Background: Congenital adrenal hyperplasia (CAH) is a rare autosomal recessive disorder, of which 21-hydroxylase deficiency (21OHD) is the most frequent form. 11 beta-hydroxylase deficiency (11bOHD) is the second most common type of CAH. This pathology results from inactivating mutations in CYP11B1 gene.Case presentation: We describe a case of a 48-year-old woman with 11bOHD, presented with hypokalemia hypertension, early adrenarche and mild vir...

Background: Gestational diabetes (GD) prevalence is increasing as the obesity epidemic continues. Its management involves hospital visits every 1–2 weeks. In 2016 our team developed a web-based telemedicine platform (SineDie©). This tool operated as a clinical decision support system designed to manage the treatment of patients with GD. SineDie© automatically prescribed diet recommendations and identified the necessity of insulin treatment....

Introduction: Fetal goiter is an infrequent and potentially life-threating condition derived from either fetal hypothyroidism or hyperthyroidism. TSH-receptor stimulating antibodies (TSH-R-ABs) can cross the placenta and induce fetal hyperthyroidism and goiter. We describe a rare case of TSH-R-ABs-induced hyperthyroidism in a woman with autoimmune hypothyroidism (AH) without previous hyperthyroidism.Case Report: A 28 years old pregnant woman under treatm...

Introduction: Surgical resection is currently considered the standard treatment for symptomatic insulinomas; however, its morbidity is high (>10%) and it is restricted to suitable candidates. In recent years, alternative minimally invasive therapies, such as endoscopic ultrasound (EUS)-guided ethanol ablation (EA), have emerged as new therapeutic options, especially for small lesions or poor surgical candidates. We report two cases of insulinoma ablated with EA.<p clas...

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause (<2 percent) of endogenous Cushing’s syndrome, usually characterized by enlarged adrenal glands containing multiple functioning nonpigmented macronodules. PBMAH was thought to be sporadic, but recently a genetic component has been described. Specifically, inactivating mutations in ARMC5 (Armadillo-repeat containing 5), a suppressor gene, have been found in many familial c...

Background: Preconception planning is essential for a successful pregnancy in women with pregestational diabetes,although many women still do not plan their pregnancies. The rapid outbreak of T2DM among the general population, including women of childbearing age, is one of the largest public health issues. The aim of this study is to describe time trends in preconception planning, obstetric and perinatal outcomesduring the past 8 years in ourpregestational care unit, focusing ...

Introduction: Stiff person syndrome (SPS) is a rare neurological disease resulting in stiffness and spasm of muscles and, as a consequence, severely impaired ambulation. Pathophysiology of the disease is based on an increased muscle activity caused by the decreased level of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) due to an autoimmune attack against glutamic acid decarboxylase (GAD); enzyme which is also one of the main autoantigens of type 1 diabetes mel...